When it gets really difficult you want to disentangle rather than to cut the knot, at least if anybody feels who is working with any thread, so anybody feels who is working with any tool so anybody feels who is writing any sentence or reading it after it has been written.
A long complicated sentence should force itself upon you, make you know yourself knowing it and the comma, well at the most a comma is a poor period that lets you
stop
and take a breath but if you want to take a breath you ought to know yourself that you want to take a breath.